Creatine monohydrate is one of the most widely used forms of creatine, a nitrogen-containing organic compound which is naturally produced by the body. It is a very important substance because it supplies the body with the energy it needs by increasing the production of adenosine triphosphate, the substance that transports energy within the cells needed for metabolism.
In a pilot study conducted among both young, healthy subjects and patients suffering from neuromuscular diseases, creatine monohydrate supplementation was shown to have increased body weight, hand grip, dorsiflexion, and knee extensor strength.
If you are suffering from either Parkinson's disease, multiple sclerosis, myasthenia gravis, Huntington's disease or the Creutzfeldt-Jakob disease, creatine monohydrate may be able to help in increasing your muscle strength and nervous control.
Creatine supplementation is popularly used to enhance sports performance, and has been successfully tested in the treatment of neuromuscular, neurological and atherosclerotic diseases. Creatine plays a key role in brain energy stability by acting as buffer for adenosine triphosphate and its regulator, adenosine diphosphate. Another experiment conducted by the Macmaster University in Hamilton, Ontario found that short term creatine monohydrate supplementation enhances high-intensity exercise performance in both males and females.
It was also shown that males that took whey protein supplements while on resistance training exhibited significant improvement in knee extension peak torque and gained more lean tissue mass than males engaged in training alone. Males that took a combination of whey protein and creatine monohydrate showed a much greater increase in lean tissue mass and bench press than those who supplemented with only whey protein or placebo.
In an experiment conducted by the University of Sydney among 45 young adults to test how oral creatine supplementation would enhance intelligence test scores and memory performance, the results show that indeed, creatine supplementation has significant positive effect on a person's intelligence and memory. This result clearly indicates that brain energy capacity plays a key role in enhancing brain performance, intelligence and memory.
Creatine plays a key role in cellular energy metabolism and can potentially play a role in protein metabolism. With regular supplementation of creatine monohydrate, young healthy men and women may experience a higher intensity exercise performance, increased skeletal muscle volume and phosphocreatine concentration, and increased fat free muscle mass.
Recent study also revealed that creatine monohydrate supplementation protects against neuromuscular as shown in laboratory animal models of Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and after ischemia. A low concentration of phosphocreatine content has also been noticed in skeletal muscles of elderly patients and of patients suffering from neuromuscular disorders.
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